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法医物证学教研室

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法医物证学教研室

教研室概况

法医物证学研室现有教授6位,副教授3位,实验师1位(博士研究生导师3位,硕士研究生导师8位),其中有国家教学名师、学科学术带头人、多种学术期刊编委。教研室人材济济,多数教师教龄在10年以上,具有丰富的教学经验,90%在职教师有短期或长期国外留学经历。教研室取得了较多的教学和科研成果,承担和主持有国家自然科学基金(重点项目、面上项目及青年基金项目、科技部“973”前期研究专项、科技部“863”主题项目、教育部博士点基金(优先发展领域及重点项目等)、科技部科技基础性工作专项、教育部科学技术研究重点项目、卫生部科学基金、四川省科技厅基金等科研项目。发表SCI论文两百余篇,获得部、省级科研成果奖及教学成果奖十余项,国家授权专利十余项。由教研室教师撰稿、主编、审校及译校的十余部专业书籍及国家级规划教材均己公开出版。法医物证学专业实验室拥有教学和科研仪器所必须的相关设备。

教学工作

本教研室承担着钱柜qg999官网研究生、七、五、三年制学生,进修生,法医学岗前培训生等不同层次、临床医学,口腔医学、预防医学、药学等不同专业学生的教学任务。主要承担的教学课程有:法医物证学、医学遗传学、法医学与司法精神病学、法医学进展与实践、法医DNA分析概述 、人类基因组研究进展等本科生和研究生课程。一贯重视教学,在教学中理论联系实际,培养学生的思考和动手能力,教书育人。

《法医物证学》2006获国家精品课程,2013年作为国家网络资源共享课首批上线;《法医学》2016年批准为国家网络资源视频公开课上线。

科学研究

通过遗传标记分析解决个人识别和亲权鉴定等法医遗传学核心问题。从降解、微量和混合斑痕检材中获得DNA并正确分型是研究的重点,包括新遗传标记与新检测技术探索、特殊案件DNA分析、灾害事故受害者的DNA鉴定、法医DNA数据库研究、法庭科学实验室的能力验证。在Y染色体和混合斑痕分析等研究领域形成了标志性成果;通过发展新的检测技术,在分析降解、微量、疑难检材等前沿领域取得了明显进展;注重以科学进步引导行业发展,通过法庭科学实验室国家认证认可等重点项目,实现科学研究与司法实践的有机结合。

承担的社会服务

法医物证鉴定

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侯一平 教授

 

学历:

1988年毕业于华西医科大学,法医学硕士

1983年毕业于四川医学院,医学学士

 

工作简历:

01/2001至今:四川大学教授

5/1995-5/1996: 德国洪堡基金会研究奖学金学者工作于不来梅大学

12/1992-12/1993:访问学者工作于德国科隆大学

12/1992-12/2000:华西医科大学教授

侯一平教授主要从事法医遗传学研究。他是博士生导师,国家教学名师,首批“国家高层次人才特殊支持计划”教学名师;四川大学法医学国家重点学科学术带头人。作为德国洪堡基金研究奖学金学者,曾在德国科隆大学、不莱梅大学从事人类分子遗传学和法医学研究。现为国务院学位委员会特种医学学科评议组召集人,国际法医遗传学会(ISFG)华语区主席。2007-2017年教育部法医学专业教学指导委员会主任委员。法医学全国规划教材编审委员会主任委员。中国法医学会教育委员会主任委员。作为项目负责人,2005年和2009年分别获得国家教学成果奖。2008年获宝钢教育基金会优秀教师特等奖。

代表论文:

1: Wang M, Wang Z, He G, Liu J, Wang S, Qian X, Lang M, Li J, Xie M, Li C, Hou Y. Developmental validation of a custom panel including 165 Y-SNPs for Chinese Y-chromosomal haplogroups dissection using the ion S5 XL system. Forensic Sci Int. 2019 Jan;38:70-76.doi: 10.1016/j.fsigen.2018.10.009. Epub 2018 Oct 11.PubMed PMID: 30352347.

2: He G, Wang Z, Wang M, Luo T, Liu J, Zhou Y, Gao B, Hou Y. Forensic ancestry analysis in two Chinese minority populations using massively parallel sequencing of 165 ancestry-informative SNPs. Electrophoresis. 2018 Nov;39(21):2732-2742.doi: 10.1002/elps.201800019. Epub 2018 Jun 28. PubMed PMID: 29869338.

3: Liu J, Wang Z, He G, Zhao X, Wang M, Luo T, Li C, Hou Y. Massively parallel sequencing of 124 SNPs included in the precision ID identity panel in three East Asian minority ethnicities. Forensic Sci Int Genet. 2018 Jul;35:141-148. doi:10.1016/j.fsigen.2018.05.002. Epub 2018 May 26. PubMed PMID: 29778045.

4: Wang Z, He G, Luo T, Zhao X, Liu J, Wang M, Zhou D, Chen X, Li C, Hou Y. Massively parallel sequencing of 165 ancestry informative SNPs in two Chinese Tibetan-Burmese minority ethnicities. Forensic Sci Int Genet. 2018 May;34:141-147. doi: 10.1016/j.fsigen.2018.02.009. Epub 2018 Feb 13. PubMed PMID:29477877.

5: Wang Z, Zhou D, Wang H, Jia Z, Liu J, Qian X, Li C, Hou Y. Massively parallel sequencing of 32 forensic markers using the Precision ID GlobalFiler™ NGS STR Panel and the Ion PGM™ System. Forensic Sci Int Genet. 2017 Nov;31:126-134. doi:10.1016/j.fsigen.2017.09.004. Epub 2017 Sep 8. PubMed PMID: 28938153.

6: Qian X, Hou J, Wang Z, Ye Y, Lang M, Gao T, Liu J, Hou Y. Next Generation Sequencing Plus (NGS+) with Y-chromosomal Markers for Forensic Pedigree Searches. Sci Rep. 2017 Sep 12;7(1):11324. doi: 10.1038/s41598-017-11955-x. PubMed PMID:28900279; PubMed Central PMCID: PMC5595879.

7: Gao T, Yun L, Gao S, Gu Y, He W, Luo H, Hou Y. Population genetics of 23 Y-STR loci in the Mongolian minority population in Inner Mongolia of China. Int J Legal Med. 2016 Nov;130(6):1509-1511. Epub 2016 Aug 12. PubMed PMID: 27515831.

8: Wang Z, Zhou D, Cao Y, Hu Z, Zhang S, Bian Y, Hou Y, Li C. Characterization of microRNA expression profiles in blood and saliva using the Ion Personal Genome Machine(®) System (Ion PGM™ System). Forensic Sci Int Genet. 2016 Jan;20:140-146.doi: 10.1016/j.fsigen.2015.10.008. Epub 2015 Nov 1. PubMed PMID: 26600000.

9: Fan G, Ye Y, Luo H, Hou Y. Use of multi-InDels as novel markers to analyze 13 X-chromosome haplotype loci for forensic purposes. Electrophoresis. 2015 Dec;36(23):2931-8. doi: 10.1002/elps.201500159. Epub 2015 Sep 17. PubMed PMID:26265037.

10: Ye Y, Gao J, Fan G, Liao L, Hou Y. Population genetics for 23 Y-STR loci in Tibetan in China and confirmation of DYS448 null allele. Forensic Sci Int Genet. 2015 May;16:e7-e10. doi: 10.1016/j.fsigen.2014.11.018. Epub 2014 Nov 29. PubMed PMID: 25524635.

11: Ren Z, Luo H, Song F, Wei W, Yang Y, Zhai X, Chen X, Hou Y. Developing a multiplex mtSNP assay for forensic application in Han Chinese based on mtDNA phylogeny and hot spot. Electrophoresis. 2015 Feb;36(4):633-9. doi:10.1002/elps.201400396. Epub 2015 Jan 2. PubMed PMID: 25382174.

12: He X, Zhang L, Chen Y, Remke M, Shih D, Lu F, Wang H, Deng Y, Yu Y, Xia Y, Wu X, Ramaswamy V, Hu T, Wang F, Zhou W, Burns DK, Kim SH, Kool M, Pfister SM, Weinstein LS, Pomeroy SL, Gilbertson RJ, Rubin JB, Hou Y, Wechsler-Reya R, Taylor MD, Lu QR. The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma. Nat Med. 2014 Sep;20(9):1035-42.

13: Li Y, Zhang J, Wei W, Wang Z, Prinz M, Hou Y. A strategy for co-analysis of microRNAs and DNA. Forensic Sci Int Genet. 2014 Sep;12:24-9. doi:10.1016/j.fsigen.2014.04.011. Epub 2014 May 2. PubMed PMID: 24858406.

14: Huang J, Luo H, Wei W, Hou Y. A novel method for the analysis of 20 multi-Indel polymorphisms and its forensic application. Electrophoresis. 2014 Feb;35(4):487-93. doi: 10.1002/elps.201300346. Epub 2013 Dec 20. PubMed PMID:24242919.

15: Wei W, Ayub Q, Chen Y, McCarthy S, Hou Y, Carbone I, Xue Y, Tyler-Smith C. A calibrated human Y-chromosomal phylogeny based on resequencing. Genome Res. 2013 Feb;23(2):388-95.

16: Chen PY, Zhang J, Luo HB, Schneider PM, Hou YP. Substitution mutation induced migration anomaly of a D10S2325 allele on capillary electrophoresis. Int J Legal Med. 2013 Mar;127(2):363-8. PubMed PMID: 23064616.

17: Wang Z, Zhang J, Luo H, Ye Y, Yan J, Hou YP. Screening and confirmation of microRNA markers for forensic body fluid identification. Forensic Sci Int Genet. 2013 Jan;7(1):116-23. PubMed PMID: 22909992.

18: Ma Y, Kuang JZ, Zhang J, Wang GM, Wang YJ, Jin WM, Hou YP. Y chromosome interstitial deletion induced Y-STR allele dropout in AMELY-negative individuals. Int J Legal Med. 2012 Sep;126(5):713-24. PubMed PMID: 22669323.

19: Zha L, Yun L, Chen P, Luo H, Yan J, Hou YP. Exploring of tri-allelic SNPs using pyrosequencing and the SNaPshot methods for forensic application. Electrophoresis. 2012 Mar;33(5):841-8. PubMed PMID: 22522538.

20: Wang Z, Luo H, Pan X, Liao M, Hou YP. A model for data analysis of microRNA expression in forensic body fluid identification. Forensic Sci Int Genet. 2012 May;6(3):419-23. PubMed PMID: 21903498.

21: Wei W, Luo HB, Yan J, Hou YP. Exploring of new Y-chromosome SNP loci using Pyrosequencing and the SNaPshot methods. Int J Legal Med. 2012 Nov;126(6):825-33. PubMed PMID: 21779922.

22: Luo HB, Ye Y, Wang YY, Liang WB, Yun LB, Liao M, Yan J, Wu J, Li YB, Hou YP. Characteristics of eight X-STR loci for forensic purposes in the Chinese population. Int J Legal Med. 2011 Jan;125(1):127-31. PubMed PMID: 19924429.

23: Zhai XD, Xue XQ, Mo YN, Zhao GS, Ai HW, Ye Y, Wang Z, Hou YP. False homozygosities at CSF1PO loci revealed by discrepancies between two kits in Chinese population. Int J Legal Med. 2010 Sep;124(5):457-8. PubMed PMID: 19876641.

24: Hou YP. Forensic DNA typing in China. Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S103-5. PubMed PMID:19282227.

25: Zhang D, Zhang D, Wu W, Luo H, Ye Y, Feng Y, Hou YP. Haplotypes of six miniY-STR loci in the Han population from Sichuan province and the Zhuang population in Guangxi Zhuang autonomous region. Forensic Sci Int Genet. 2009 Mar;3(2):e49-51. PubMed PMID: 19215867.

26: Zhang H, Li Y, Jiang J, Zhang J, Wu J, Du H, Yan J, Shen Y, Hou YP. Analysis of 15 STR loci in Chinese population from Sichuan in West China. Forensic Sci Int. 2007 Sep 13;171(2-3):222-5. PubMed PMID: 16806770.

27: Yan J, Wu J, Li Y, Wang H, Huang Z, Zhou X, Zhang W, Hou YP. A novel diagnostic strategy for trisomy 21 using short tandem repeats. Electrophoresis.2006 Feb;27(2):416-22. PubMed PMID: 16342319.

28: Dai HL, Wang XD, Li YB, Wu J, Zhang J, Zhang HJ, Dong JG, Hou YP. Characterization and haplotype analysis of 10 novel Y-STR loci in Chinese Han population. Forensic Sci Int. 2004 Oct 4;145(1):47-55. PubMed PMID: 15374594.

29: Hou YP, Zhang J, Sun D, Li Y, Wu J, Zhang S, Prinz M. Typing Y chromosome STR haplotypes using redesigned primers. J Forensic Sci. 2002 Jan;47(1):215-7. PubMed PMID: 12064657.

30: Hou YP, Tang JP, Dong JG, Ji Q, Li YB, Wu J, Zhang SZ, Zhang J, Yan J, Walter H, Prinz M. Further characterization and population data for the pentanucleotide STR polymorphism D10S2325. Forensic Sci Int. 2001 Dec 1;123(2-3):107-10. PubMed PMID: 11728734.

31: Hou YP, Zhang J, Li YB, Wu J, Zhang SZ, Prinz M. Allele sequences of six new Y-STR loci and haplotypes in the Chinese Han population. Forensic Sci Int. 2001 May 15;118(2-3):147-52. PubMed PMID: 11311828.

32: Hou YP, Jin ZM, Li YB, Wu J, Walter H, Kido A, Prinz M. D20S161 data for three ethnic populations and forensic validation. Int J Legal Med.1999;112(6):400-2. PubMed PMID: 10550605.

主编的部分教材:

(1) 法医学,第7版,人民卫生出版社,北京,2018.7

(2) 法医物证学,第4版,人民卫生出版社,北京,2016.3

(3) 法医学,第3版,高等教育出版社,北京,2015.3

(4) 法医学,第6版,人民卫生出版社,北京,2013.3

(5) 法医物证学,第3版,人民卫生出版社,北京,2009.7

(6) 法医学,第2版,高等教育出版社,北京,2008.9

(7) 法医物证学,第2版,人民卫生出版社,北京,2004.6

(8) 法医学,第1版,高等教育出版社,北京,2004.1

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张 林 教授

 

学历:

1995年毕业于德国美因茨大学,医学博士

1987年毕业于华西医科大学,法医学硕士

1984年毕业于四川医学院,法医学学士

 

工作简历:

09/2000至今: 四川大学教授

08/1995-01/1999: 德国美因茨大学医学院博士后

12/1999-09/2000: 华西医科大学教授

张林教授主要从事免疫学及法医遗传学研究。他是博士生导师,国务院政府特殊津贴获得者,卫生部有突出贡献的中青年专家,教育部跨世纪人才,四川省科学与技术学术带头人,首届四川省卫生计生领军人才。获德国DFG基金会资助,曾在德国Mainz大学从事人类分子遗传学和法医学研究。现任2018-2022年教育部法医学专业教学指导委员会主任委员。获科技部“973”、“863”、科技基础性工作专项、自然科学基金、教育部重点项目、四川省重大科技专项等多项基金资助。获省部级科技进步一、二等奖6项、发表SCI论文150余篇,主编国家“十一五”规划教材2部,主编及参编专业教材及著作4部,培养硕、博士研究生50余名。

代表论文:

1. B. Zhou, M. Qie, Y. Wang, L. Yan, Z. Zhang, A. Liang, T. Wang, X. Wang, Y. Song, and L. Zhang, "Relationship between NFKB1 -94 insertion/deletion ATTG polymorphism and susceptibility of cervical squamous cell carcinoma risk,"Ann Oncol,vol. 21, no. 3, pp. 506-11, 2010.

2. B. Zhou, L. Rao, Y. Li, L. Gao, Y. Wang, Y. Chen, H. Xue, Y. Song, Y. Peng, M. Liao, and L. Zhang, "A functional insertion/deletion polymorphism in the promoter region of NFKB1 gene increases susceptibility for nasopharyngeal carcinoma,"Cancer Lett,vol. 275, no. 1, pp. 72-6, 2009.

3. L. B. Gao, L. Rao, Y. Y. Wang, W. B. Liang, C. Li, H. Xue, B. Zhou, H. Sun, Y. Li, M. L. Lv, X. J. Du, and L. Zhang, "The association of interleukin-16 polymorphisms with IL-16 serum levels and risk of colorectal and gastric cancer,"Carcinogenesis,vol. 30, no. 2, pp. 295-9, 2009.

4. L. B. Gao, X. M. Pan, J. Jia, W. B. Liang, L. Rao, H. Xue, Y. Zhu, S. L. Li, M. L. Lv, W. Deng, T. Y. Chen, Y. G. Wei, and L. Zhang, "IL-8 -251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis,"Eur J Cancer,vol. 46, no. 8, pp. 1333-43, 2010.

5. K. Zhang, B. Zhou, Y. Wang, L. Rao, and L. Zhang, "The TLR4 gene polymorphisms and susceptibility to cancer: a systematic review and meta-analysis,"Eur J Cancer,vol. 49, no. 4, pp. 946-54, 2013.

6. K. Zhang, B. Zhou, Y. Wang, L. Rao, and L. Zhang, "Response to letter 'An updated meta-analysis about the association of Asp299Gly in Toll-like receptor 4 gene with risk of cancer',"Eur J Cancer,vol. 49, no. 8, pp. 2071-2, 2013.

7. K. Zhang, B. Zhou, Y. Wang, L. Rao, and L. Zhang, "Response to letter 'A cumulative meta-analysis on the association of toll-like receptor 4 gene Asp299Gly polymorphism with cancer risk',"Eur J Cancer,vol. 58, pp. 138-9, 2016.

8. W. Chen, H. Li, Y. Jia, M. Lv, M. Li, P. Feng, H. Hu, and L. Zhang, "In vivo administration of plasmid DNA encoding recombinant immunotoxin DT390-IP-10 attenuates experimental autoimmune encephalomyelitis,"J Autoimmun,vol. 28, no. 1, pp. 30-40, 2007.

9. L. B. Gao, X. M. Pan, H. Sun, X. Wang, L. Rao, L. J. Li, W. B. Liang, M. L. Lv, W. Z. Yang, and L. Zhang, "The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis,"J Exp Clin Cancer Res,vol. 29, pp. 117, 2010.

10. L. Li, R. Sun, Y. Liang, X. Pan, Z. Li, P. Bai, X. Zeng, D. Zhang, L. Zhang, and L. Gao, "Association between polymorphisms in long non-coding RNA PRNCR1 in 8q24 and risk of colorectal cancer,"J Exp Clin Cancer Res,vol. 32, pp. 104, 2013.

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张霁教授

张霁,2004年毕业于四川大学法医学专业并获博士学位,2007年在美国哈佛医学院从事博士后研究,2011年回国,并任四川大学大学华西基础与法医学院法医物证学教研室教授,博士研究生导师。四川省法医学会常务理事、四川省学术和技术带头人后备人选、四川省卫生计生委学术技术带头人、国务院学位委员会特种医学学科评议组秘书,是“十三五”国家级规划教材《法医物证学》、《法医学》编委。

主要从事法医遗传学研究工作,目前主要研究方向有:1.基于全基因组扩增、全转录组扩增、微乳滴PCR体系的高灵敏度DNA、RNA遗传标记检测体系研究。2.SNP、InDel遗传标记构成的微单倍型及其在混合DNA分析、亲缘关系鉴定中的应用研究。3.基于SNP或InDel位点的等位基因特异性引物PCR-STR检测体系的构建及其在混合斑分析中的应用研究。4.基于微生物DNA条码基因焦磷酸测序的微生物群落一致性分析的法医微生物学研究。5.族源信息遗传标记研究。

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梁伟波 教授

 

学历:

2006年毕业于四川大学,法医学博士

2001年毕业于四川大学,法医学学士

 

工作简历:

2007年至今:四川大学教授

2012-2013:访问学者工作于德国科隆大学医学院法医学研究所

梁伟波教授主要从事法医遗传学研究,硕士生导师,德国科隆大学访问学者。四川省科学与技术学术带头人后备人选,2018-2022年教育部法医学专业教学指导委员会秘书长,中国法医学会会员,国际法医遗传学会委员会成员,四川省法医学学会常务理事。获得三项国家自然科学基金,一项四川省科技厅科技支撑面上项目资助。研究成果陆续发表在法医遗传学领域顶级期刊Forensic Science International: Genetics,International Journal of Legal Medicine等杂志上。参加国家卫生和计划生育委员会“十三五”规划法医学专业类教材编写。

部分论文:

1: Zhu J, Lv M, Zhou N, Chen D, Jiang Y, Wang L, He W, Peng D, Li Z, Qu S, Wang Y, Wang H, Luo H, An G, Liang W, Zhang L. Genotyping polymorphic microhaplotype markers through the Illumina® MiSeq platform for forensics. Forensic Sci Int Genet. 2018 Nov 16;39:1-7. doi: 10.1016/j.fsigen.2018.11.005. [Epub ahead of print]. PubMed PMID: 30472641

2: Tan Y, Bai P, Wang L, Wang H, Tian H, Jian H, Zhang R, Liu Y, Liang W, Zhang L. Two-person DNA mixture interpretation based on a novel set of SNP-STR markers. Forensic Sci Int Genet. 2018 Nov;37:37-45. doi: 10.1016/j.fsigen.2018.07.021. Epub 2018 Jul 26. PubMed PMID: 30075395

3: Wang Q, Jin B, An G, Zhong Q, Chen M, Luo X, Li Z, Jiang Y, Liang W, Zhang L. Rapidly mutating Y-STRs study in Chinese Yi population. Int J Legal Med. 2018 Jul 30. doi: 10.1007/s00414-018-1894-5. [Epub ahead of print]. PubMed PMID: 30062654

4: Chen P, Zhu W, Tong F, Pu Y, Yu Y, Huang S, Li Z, Zhang L, Liang W, Chen F. Identifying novel microhaplotypes for ancestry inference. Int J Legal Med. 2018 Jun 23. doi: 10.1007/s00414-018-1881-x. [Epub ahead of print]. PubMed PMID: 29936540

5: Chen P, Yin C, Li Z, Pu Y, Yu Y, Zhao P, Chen D, Liang W, Zhang L, Chen F. Evaluation of the Microhaplotypes panel for DNA mixture analyses. Forensic Sci Int Genet. 2018 Jul;35:149-155. doi: 10.1016/j.fsigen.2018.05.003. Epub 2018 May 12. PubMed PMID: 29778046

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编写的部分教材:

(9) 生物物证采集与检验教程,第1版,中国文史出版社,北京,2016.9

(10)法医物证学实验指导,第2版,人民卫生出版社,北京,2016.3

(11)法医昆虫学,第1版,人民卫生出版社,北京,2015.12

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