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王 魁

发布时间:2020-03-06      作者:学科办      审核:      编辑:蒋宝晴      点击:
审核人

 姓名:王魁 

 职称:副研究员

简历

2015年毕业于四川大学生物治疗国家重点实验室,获理学博士学位,随后在四川大学华西医院从事博士后研究。2018年3月任四川大学华西基础医学与法医学院副研究员。2013年作为访问学者赴澳大利亚莫纳什大学(Monash University)学习交流1年。入选四川大学青年科技学术带头人培育项目(2019)、第十三批四川省卫生健康委员会学术技术带头人后备人选;获四川大学学术新人奖(2018)、四川大学青年科技人才奖(2018)、四川大学好未来优秀学者奖(2019)。

以第一/共同第一作者或共同通讯作者在Trends Biochem Sci (IF: 16.89)、Hepatology (IF: 14.97)、Autophagy (IF: 11.06,4篇)、Cancer Res (IF: 9.12,肿瘤学权威期刊)、Med Res Rev (IF: 9.79)等国际学术刊物发表SCI论文20篇,其中6篇影响因子大于10分,13篇影响因子大于5分。被包括 Cell, Nat Rev Drug Discov, Nat Rev Microbiol 等在内的国际学术期刊引用1400余次,单篇最高被引用244次。任国际学术刊物 Expert Rev Proteomics 期刊编委委员(2019--);Mol CancerTheranosticsCancer LettSignal Transduct Target Ther 等国际学术刊物特邀审稿人。先后承担国家自然科学基金青年科学基金项目、面上项目和中国博士后科学基金第10批特别资助项目等,作为项目骨干参与国家自然科学基金重大项目和重点项目。

研究方向

1.代谢、氧化还原信号调控、自噬与肿瘤发生发展

2.药物靶点筛选、鉴定和作用机制研究

联系方式

邮箱:wangkui416@163.com(常用);kuiwang@scu.edu.cn

电话:13550343240

代表性论著】(*共同第一作者;#共同通讯作者)

1.Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C. Targeting Metabolic-Redox Circuits for Cancer Therapy.Trends Biochem Sci. 2019;44(5):401-14. (IF: 16.89)

2.Jiang J, Zhang L, Chen H, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y,Wang K#, Huang C#. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.Autophagy. 2020;16(1):106-22. (IF: 11.06;共同通讯作者)

3.Huang Z*, Zhou JK*,Wang K*, Chen H, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C, Wei X, Peng Y. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma.Hepatology. 2020; doi: 10.1002/hep.30930. (IF: 14.97;共同第一作者).

4.Wang K, Liu R, Li J, Mao J, Lei Y, Wu J, Zeng J, Zhang T, Wu H, Chen L, Huang C, Wei Y. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling.Autophagy. 2011;7(9):966-78. (IF: 11.06;被引用244)

5.Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M, Huang C, Wei Y.Identification of ANXA2 (annexin A2) as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux.Autophagy.2018;14(2):269-82. (IF: 11.06)

6.Lei Y*,Wang K*, Li X*, Li Y, Feng X, Zhou J, Zhang Z, Huang C, Zhang T.Cell-surface Translocation of Annexin A2 contributes to bleomycin-induced pulmonary fibrosis by mediating inflammatory response in mice.Clin Sci. 2019;133(7):789-804. (IF: 5.24;共同第一作者)

7.Wang K, Chen Y, Zhang P, Lin P, Xie N, Wu M. Protective Features of Autophagy in Pulmonary Infection and Inflammatory Diseases.Cells. 2019;8(2). pii: E123. (IF: 5.66)

8.Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C. Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer.Autophagy. 2016;12(12):2498-9. (IF: 11.06)

9.Dou Q*, Chen HN*,Wang K*, Yuan K*, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y, Huang C. Ivermectin Induces Cytostatic Autophagy by Blocking the PAK1/Akt Axis in Breast Cancer.Cancer Res. 2016;76(15):4457-69.(IF: 9.12;共同第一作者)

10.Wang K, Zhang T, Dong Q, Nice EC, Huang C, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.Cell Death Dis. 2013;14;4:e537.(IF: 5.96;被引用186)

11.Lei Y*,Wang K*, Deng L*, Chen Y, Nice EC, Huang C. Redox Regulation of Inflammation: Old Elements, a New Story.Med Res Rev. 2015;35(2):306-40. (IF:9.79;共同第一作者)

12.Jiang J*,Wang K*, Chen Y*, Chen H, Nice EC, Huang C.Redox regulation in tumor cell epithelial-mesenchymal transition: Molecular basis and therapeutic strategy.Signal Transduct Target Ther.2017;2:e17036.(IF: 5.87,*共同第一作者)

13.Zhang L*,Wang K*, Lei Y, Li Q, Nice EC, Huang C. Redox signaling: Potential arbitrator of autophagy and apoptosis in therapeutic response.Free Radic Biol Med. 2015;89:452-65.(IF: 5.66;共同第一作者)

14.Ren F*,Wang K*, Zhang T, Jiang J, Nice EC, Huang C. New insights into redox regulation of stem cell self-renewal and differentiation.BBA-Gen Subjects. 2015;1850(8):1518-26. (IF: 3.68;共同第一作者)

15.Wang K, Huang C, Nice EC. Proteomics, genomics and transcriptomics: their emerging roles in the discovery and validation of colorectal cancer biomarkers.Expert Rev Proteomics. 2014;11(2):179-205.(IF: 3.85)

16.Wang K, Yang T, Wu Q, Zhao X, Nice EC, Huang C. Chemistry-based functional proteomics for drug target deconvolution.Expert Rev Proteomics. 2012;9(3):293-310. (IF: 3.85)

17.Jin P*,Wang K*, Huang C, Nice EC. Mining the fecal proteome: from biomarkers to personalised medicine.Expert Rev Proteomics. 2017;14(5):445-459.(IF: 3.85;共同第一作者)

18.Zhou L*,Wang K*, Li Q, Nice EC, Zhang H, Huang C. Clinical proteomics-driven precision medicine for targeted cancer therapy: current overview and future perspectives.Expert Rev Proteomics. 2016;13(4):367-81. (IF: 3.85;共同第一作者)

19.Jiang J*,Wang K*, Nice EC, Zhang T, Huang C. High-throughput screening of cellular redox sensors using modern redox proteomics approaches.Expert Rev Proteomics. 2015;12(5):543-55. (IF: 3.85;共同第一作者)

20.Wang K, Huang C, Nice E. Recent advances in proteomics: towards the human proteome.Biomed Chromatogr. 2014;28(6):848-57. (IF: 1.75)

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