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黄灿华

发布时间:2018-07-17      作者:学院办公室      审核:      编辑:      点击:
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      黄灿华,四川大学华西基础医学与法医学院院长,四川大学生物治疗国家重点实验室教授

      【简历】

      2000年在中国科学院获博士学位,随后在新加坡国立大学生物系从事博士后研究。2003年8月被新加坡国立大学肿瘤研究所聘为Research Scientist。2005年9月回国任四川大学生物治疗国家重点实验室教授,2017年至今任四川大学华西基础医学与法医学院院长。国家杰出青年科学基金获得者(2012);国家重大科学研究计划(973计划)“病毒诱导肿瘤发生的氧化还原蛋白质组研究”项目首席科学家(2013-2017);国家自然科学基金委“氧化还原信号调控与肿瘤发生发展”创新群体项目负责人(2018);四川省生物化学与分子生物学会理事长;四川省政协委员;成都市欧美同学会副秘书长;成都统一战线“同心智库”专家成员;享受国务院特殊津贴专家(2018)。

      回国以来以通讯作者在GastroenterologyNat MicrobiolNat CommunJ HepatolHepatologyAutophagy(8篇)、Cancer Res(3篇,包括2013封面论文)、Cell Death DifferMol Cell Proteomics(5篇)等国际学术刊物出版论文80余篇。受邀请在Trends Biochem SciMass Spectrom RevMed Res RevExpert Rev Proteomics 等国际学术刊物上发表多篇关于系统生物学前沿综述。国际学术刊物ProteomicsSignal Transduction and Targeted Therapy 等编委委员。

      【研究方向】

      (1)氧化还原信号调控与肿瘤发生发展

      (2)病毒诱发癌变的分子机理

      【联系方式】

      邮箱:hcanhua@hotmail.com(常用); hcanhua@scu.edu.cn

      电话:+86-13258370346

      实验室主页:黄灿华教授实验室

      国重主页:黄灿华-生物治疗国家重点实验室            

      【代表性论著】(*为通讯作者)

      • 1. Huang Z, Zhou J-K, Wang K, Chen H-N, Qin S, Liu J, Luo M, Chen Y, Jiang J, Zhou L, Zhu L, He J, Li J, Pu W, Gong Y, Li J, Ye Q, Dong D, Hu H, Zhou Z, Dai L, Wei Y, Huang C*, Wei X*, Peng Y*. PDLIM1 inhibits tumor metastasis through activating Hippo signaling in hepatocellular carcinoma. Hepatology. 2019; doi:10.1002/hep.30930.

      • 2. Zhang Z, Gao W, Zhou L, Chen Y, Qin S, Zhang L, Liu J, He Y, Lei Y, Chen H-N, Han J, Zhou Z-G, Nice EC, Li C, Huang C*, Wei X*. Repurposing Brigatinib for the Treatment of Colorectal Cancer Based on Inhibition of ER-phagy.Theranostics. 2019; 9(17):4878-4892.

      • 3. Jiang J, Zhang L, Chen H-N, Lei Y, Zhang T, Wang Y, Jin P, Lan J, Zhou L, Huang Z, Li B, Liu Y, Gao W, Xie K, Zhou L, Nice EC, Peng Y, Cao Y, Wei Y, Wang K*, Huang C*. Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma.Autophagy. 2020;16(1):106-122.

      • 4. Chen H-N, Chen Y, Zhou Z-G, Wei YQ, Huang C*. A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery.Autophagy. 2019;15(4):733-734.

      • 5. Zhou L, Gao W, Wang K, Huang Z, Zhang L, Zhang Z, Zhou J, Nice EC, Huang C*. Brefeldin A Inhibits Colorectal Cancer Growth by Triggering Bip/Akt-regulated Autophagy.FASEB J. 2019;33(4):5520-5534.

      • 6. Wang K, Jiang J, Lei Y, Zhou S, Wei Y, Huang C*. Targeting Metabolic-redox Circuits for Cancer Therapy.Trends Biochem Sci. 2019;44(5):401-414.

      • 7. Zhang Z, Zhang L, Zhou L, Lei Y, Zhang Y*, Huang C*. Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress.Redox Biol. 2019;25:101047.

      • 8. Chen Y, Chen H-N, Wang K, Zhang L, Huang Z, Liu JY, Zhang Z, Luo MC, Lei YL, Peng Y, Zhou Z-G, Wei YQ, Huang C*. Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.J Hepatol. 2019;70(1):66-77.

      • 9. Liu Y, Guo JZ, Liu Y, Wang K, Ding W, Wang H, Liu X, Zhou S, Lu XC, Yang HB, Xu C, Gao W, Zhou L, Wang YP, Hu W, Wei Y, Huang C*, Lei QY*. Nuclear Lactate Dehydrogenase A Senses ROS to Produce α-Hydroxybutyrate for HPV-induced Cervical Tumor Growth.Nat Commun. 2018;9(1):4429.

      • 10. Lan J, Huang Z, Han J, Shao J*, Huang C*. Redox regulation of microRNAs in cancer.Cancer Lett. 2018;418:250-259.

      • 11. Wang K, Zhang T, Lei Y, Li X, Jiang J, Lan J, Liu Y, Chen H, Gao W, Xie N, Chen Q, Zhu X, Liu X, Xie K, Nice EC, Wu M*, Huang C*, Wei Y. Identification of Annexin A2 as a Specific Bleomycin Target to Induce Pulmonary Fibrosis by Impeding TFEB-mediated Autophagic Flux.Autophagy. 2018;29:1-14.

      • 12. Wang K, Gao W, Dou Q, Chen H, Li Q, Nice EC, Huang C*. Ivermectin Induces PAK1-mediated Cytostatic Autophagy in Breast Cancer.Autophagy. 2016;12(12)2498-2499.

      • 13. Dou Q, Chen H, Wang K, Yuan K, Lei Y, Li K, Lan J, Chen Y, Huang Z, Xie N, Zhang L, Xiang R, Nice EC, Wei Y and Huang C*. Ivermectin induces cytostatic autophagy by blocking PAK1/Akt axis in breast cancer.Cancer Res. 2016;76(15):4457-69.

      • 14. Li X, He S, Li R, Zhou X, Zhang S, Yu M, YeY, Wang Y, Huang C*, Wu M*. Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-ediated immune activation and infiltration.Nat Microbiol. 2016;1(10):16132.

      • 15. Xie N, Yuan K, Zhou L, Wang K, Chen H, Lei Y, Lan J, Pu Q, Gao W, Zhang L, Shen G, Li Q, Xiao H, Tang H, Xiang R, He M, Feng P, Nice EC, Wei Y, Zhang H*, Yang J* and Huang C*. PRKAA1/AMPK restricts HBV replication through promotion of autophagic degradation.Autophagy. 2016;12(9):1507-20.

      • 16. Huang Z, Zhou L, Chen Z, Nice EC, Huang C*. Stress Management by Autophagy: Implications for Chemoresistance.Int J Cancer. 2016;139(1):23-32.

      • 17. Chen HN, Yuan K, Xie N, Wang K, Huang Z, Chen Y, Dou Q, Wu M, Nice EC, Zhou ZG*, Huang C*. PDLIM1 stabilizes the E-cadherin/Beta-catenin complex to prevent epithelial-mesenchymal transition and metastatic potential of colorectal cancer cells.Cancer Res. 2016;76(5):1122-34.

      • 18. Yuan K, Lei Y, Chen H, Chen Y, Zhang T, Li K, Xie N, Wang K, Feng X, Pu Q, Yang W, Wu Min, Xiang R, Feitelson MA, Nice EC, Wei Y, Huang C*. HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.Cell Death Differ. 2016;616–627.

      • 19. Li X, He S, Zhou X, Ye Y, Tan S, Zhang S, Li R, Yu M, Jundt MC, Hidebrand A, Wang Y, Li G*, Huang C*, Wu M*. Lyn delivers bacteria to lysosomes for eradication through TLR2-initiated autophagy related phagocytosis.PLoS Pathog. 2016;12(1):e1005363.

      • 20. Zhang L, Wang K, Lei Y, Li Q, Nice EC, Huang C*. Redox Signaling: Potential Arbitrator of Autophagy and Apoptosis in Therapeutic Response.Free Radical Bio Med. 2015;89:452-465.

      • 21. Lei Y, Wang K, Deng L, Chen Y, Nice EC, Huang C*. Redox Regulation of Inflammation: Old Elements, a New Story.Med Res Rev. 2015;35(2):306-40.

      • 22. Liu R, Li J, Zhang T, Zou L, Chen Y, Wang K, Lei Y, Yuan K, Li Y, Lan J, Cheng L, Xie N, Xiang R, Nice EC, Huang C*, Wei Y. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking.Autophagy. 2014;10(7):1241-55.

      • 23. Liu R, Li J, Xie K, Zhang T, Lei Y, Chen Y, Zhang L, Huang K, Wang K, Wu H, Wu M, Nice EC, Huang C*, Wei Y. FGFR4 promotes stroma-induced epithelial to mesenchymal transition in colorectal cancer.Cancer Res. 2013;73(19):5926-35. (2013, Oct 1st,封面论文;Highlighted as breaking advance inCancer Res, 2013, Oct 15th )

      • 24. Wen X, Wu J, Wang F, Liu B*, Huang C*, Wei Y. Deconvoluting the role of reactive oxygen species and autophagy in human diseases.Free Radic Biol Med. 2013;65:402-10.

      • 25. Liu R, Huang L, Li J, Zhou X, Zhang H, Zhang T, Lei Y, Wang K, Xie N, Zheng Y, Wang F, Nice EC, Rong L, Huang C*, Wei Y. HIV Infection in Gastric Epithelial Cells.J Infect Dis. 2013;208(8):1221-30.

      • 26. Wu J, Xie N, Xie K, Zeng J, Cheng L, Lei Y, Liu Y, Song L, Dong D, Chen Y, Zeng R, Nice EC, Huang C*, Wei Y. GPR48, a poor prognostic factor, promotes tumor metastasis and activates β-catenin/TCF signaling in colorectal cancer.Carcinogenesis. 2013;34(12):2861-9.

      • 27. Yuan K, Xie K, Fox J, Zeng H, Gao H, Huang C*, Wu M*. Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Tumor Growth and Metastasis in Mice.Gastroenterology. 2013;145(4):853-64.e9

      • 28. Deng L, Lei Y, Liu R, Li J, Yuan K, Li Y, Chen Y, Liu Y, Lu Y, Edwards CK 3rd, Huang C*, Wei Y. Pyrvinium targets autophagy addiction to promote cancer cell death.Cell Death Dis. 2013;4:e614.

      • 29. Wang K, Zhang T, Dong Q, Nice EC, Huang C*, Wei Y. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation.Cell Death Dis. 2013;4:e537

      • 30. Zhou S, Liu R, Yuan K, Yi T, Zhao X, Huang C*, Wei Y. Proteomics analysis of tumor microenvironment: Implications of metabolic and oxidative stresses in tumorigenesis.Mass Spectrom Rev. 2013;32(4):267-311

      • 31. Zhou S, Yi T, Liu R, Bian C, Qi X, He X, Wang K, Li J, Zhao X*, Huang C*, Wei Y. Proteomics identification of annexin A2 as a key mediator in the metastasis and proangiogenesis of endometrial cells in human adenomyosis.Mol Cell Proteomics. 2012;11(7):M112.017988

      • 32. Lei Y, Huang K, Gao C, Lau QC, Pan H, Xie K, Li J, Liu R, Zhang T, Xie N, Shan Nai H, Wu H, Zhao X, Dong Q, Nice E, Huang C*, Wei Y. Proteomics identification of ITGB3 as a key regulator in ROS-induced migration and invasion of colorectal cancer cells.Mol Cell Proteomics. 2011;10(10):M110.005397.

      • 33. Yuan K, Huang C*, Fox J, Gaid M, Weaver A, Li GP, Singh BB, Gao H, Wu M*. Elevated inflammatory response in Caveolin-1 deficient mice with P. aeruginosa infection is mediated by STAT3 and NF-{kappa}B.J Biol Chem. 2011;286(24):21814-25

      • 34. Zhou S, Li Y, Huang F, Zhang B, Yi T, Li Z, Luo H, He X, Zhong Q, Bian C, Lin X, Qi X, Liu P, Huang C, Zhao X*, Wei Y. Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation.Cancer Lett. 2012;318(1):14-25.

      • 35. Wang K, Liu R, Li J, Mao J, Xie N, Wu J, Lei Y, Zhang T, Zeng J, Wu H, Chen L, Huang C.* Wei Y. Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling.Autophagy. 2011;7(9):966-78

      • 36. Li J, Liu R, Lei Y, Wang K, Lau Q.C, Xie N, Zhou S, Nie C, Chen L, Wei Y, and Huang C*. Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells.Autophagy. 2010;6(6) :711-24

      • 37. Ren F, Wu H, Lei Y, Zhang H, Liu R, Zhao Y, Zeng D, Tong A, Chen L, Wei Y, Huang C*. Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma.Mol Cancer. 2010;9:81

      • 38. Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, Chen L, Liang S, Zhao Y, Wei Y, Huang C*. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone mediated gastric carcinogenic signaling pathway.Mol Cell Proteomics. 2009;8(1):70-85

      • 39. Li Z, Zhao X*, Bai S, Wang Z, Chen L, Wei Y, Huang C*. Proteomic identification of cyclophilin A as a potential prognostic factor and therapeutic target in endometrial carcinoma.Mol Cell Proteomics. 2008;7(10):1810-1823

      • 40. Wang Z, Jiang L, Huang C*, Li Z, Tong A, Chen L, Shen J, Gao F, Chen Q*. Comparative proteomic approach to screening of potential diagnostic and therapeutic targets for Oral Squamous Cell Carcinoma.Mol Cell Proteomics. 2008;7:1639–1650

      • 41. Li Z, Huang C*, Bai S, Pan X, Zhou R, Wei Y, and Zhao X*. Prognostic evaluation of epidermal fatty acid-binding protein and calcyphosine, two proteins implicated in endometrial cancer using a proteomic approach.Int J Cancer. 2008;123:2377-2383

       

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