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张舒羽

发布时间:2019-10-12      作者:      审核:      编辑:吴靓      点击:
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张舒羽特聘研究员

张舒羽特聘研究员主要从事放射性皮肤损伤的机理与防治策略。近年来,共主持国家自然科学基金项目四项、省部级项目五项。2015年获得国家自然科学基金优秀青年科学基金,2019年获得中国核工业集团(原核工业部)菁英人才项目。带领团队采用多维“组学”手段系统的探索了放射性皮肤损伤、放射性肺损伤等进展过程中的分子谱学变化,揭示了氧化应激开关、自由基级联效应、蛋白酶体通路、锌离子稳态等在调控急性辐射损伤进展及晚期纤维化中的作用机制,并为辐射损伤防治提供了新的思路和策略。发表SCI论文60余篇,第一作者和/或通讯作者论文40余篇,分别发表在 J Invest DermatolInt J Radiat Oncol*Biol*Phys、OncogeneFree Radical Biol & MedCarcinogenesisRadiat Res Radiat Oncol 等杂志上;被发表在 Nat GenetPNASGenome ResAntioxid Redox SignalJ Invest DermatolOncogene Nucleic Acid Res 等高影响力杂志上论文引用。部分研究受到国际同行的关注,被加拿大 Global Medical Discovery 网站以亮点论文报道。担任 SCI 源期刊 Exp Ther Med 中华放射医学和防护杂志、国际放射医学核医学杂志编委;被TheranosticsCarcinogenesisBBA(Basic Mechanism of Disease)、ApoptosisInt J Biol Sci Dose Response 等二十余杂志邀请为审稿人。获得国家发明专利8项(第一发明人4项)。为主获教育部技术发明二等奖和中国核能行业协会(省部级)技术发明二等奖。

代表性论文:*通讯作者)

1. Qiu Y, Gao Y, Yu D, Zhong L, Cai W, Ji J, Geng F, Tang G, Zhang H, Cao J, Zhang J*,Zhang S*. Genome-wide analysis reveals zinc transporter ZIP9 regulated by DNA methylation promotes radiation-induced skin fibrosis via the TGF-β signaling pathway.J Invest Dermatol. 2020;140:94-102.

2. Xiao Y, Mo W, Jia H, Yu D, Qiu Y, Jiao Y, Zhu W, Koide H, Cao J*,Zhang S*. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury.J Dermatol Sci. 2020;97(2):152-160.

3. Cao J, Zhu W, Yu D, Pan L, Zhong L, Xiao Y, Gao Y, Jiao Y, Zhang Q, Ji J, Yang H,Zhang S*, Cao J*. The Involvement of SDF-1α/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin.Radiat Res. 2019;192(4):410-421.

4.Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, Cao J, Cao J, Huang Z, Zhou X*,Zhang S*. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.Cancer Sci. 2019;110(3):962-972.

5.Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J*,Zhang S*. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway.Oncogene. 2018;37(7):953-962.

6. Xue J, Yu C, Sheng W, Zhu W, Luo J, Zhang Q, Yang H, Cao H, Wang W, Zhou J, Wu J, Cao P, Chen M, Ding WQ, Cao J*,Zhang S*. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade.J Invest Dermatol. 2017;137(10):2059–2068.

7. Song J, Zhang H, Wang Z, Xu W, Zhong L, Cao J, Yang J, Tian Y, Yu D, Ji J*, Cao J,Zhang S*. The Role of FABP5 in Radiation-Induced Human Skin Fibrosis.Radiat Res. 2018;189(2):177-186.

8. Nie J, Zhang J, Wang L, Lu L, Yuan Q, An F,Zhang S*, Jiao Y*. Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4.J Exp Clin Cancer Res. 2017;36(1):183.

9. Wang W, Luo J, Sheng W, Xue J, Li M, Ji J, Liu P, Zhang X, Cao J,Zhang S*. Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system.Int J Radiat Oncol*Biol*Phys.2016;95(2):751-60.

10. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Cheng G, Zhou Q, Wang W, Zhou X, Luo J*,Zhang S*. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells.J Exp Clin Cancer Res. 2016;35(1):7.

11.Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ*. The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in cancer cells: The involvement of the RNA binding protein AUF1.Free Radic Biol Med.2015,85:33-44.

12.Zhang S*, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J*, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 (PRDX-6) against ionizing radiation.Free Radical Biol & Med. 2014;69:96-107.

13.Zhang S, Chen H, Zhao S, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D*. REV3L 3’UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility.Oncogene.2013:10;32(2):242-50.

14.Zhang S*, Hao J, Xie F, Hu X, Liu C, Tong J, Zhou J, Wu J, Shao C*. Downregulation of miR-132 by promoter methylation contributes to pancreatic cancer development.Carcinogenesis. 2011;32(8):1183-9.

15.Zhang S, Lu J, Zhao X, Wu W, Wang H, Lu J, Wu Q, Chen X, Fan W, Wang F, Hu Z, Jin L, Wei Q, Shen H, Huang W, Lu D*.A variant in theCHEK2promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.Carcinogenesis. 2010;31:2151-2158.

联系方式:zhangshuyu@scu.edu.cn

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