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周 华

发布时间:2016-06-03      作者:学院办公室      审核:      编辑:      点击:
审核人

    教授

    生理教研室

    四川大学华西基础医学与法医学院

    地址:

    四川省人民南路三段17号

    电话:+86-28-85503048

    Email地址:zhouhua_01@163.com

    1987年毕业于西安医科大学医学系,获医学学士学位,1997年获华西医科大学医学硕士学位,2005年获四川大学理学博士学位。现任四川大学华西医学中心基础医学与法医学院生理教研室教授。

    在教学方面,长期从事本科生和研究生教学工作,获教改项目和教学成果奖多项。

    在科研方面,主要从事与中枢神经系统兴奋性活动相关的系统和细胞生物学研究。熟练掌握整体神经元放电记录、细胞外微电极记录、全细胞膜片钳技术等电生理学研究方法。主要研究工作包括大鼠癫痫发生的机制研究、神经保护剂对抗缺血缺氧所致细胞损伤机制的研究。

    先后赴香港大学医学院生理系、美国哈佛大学医学院附属Brigham and Women’s Hospital作学术研究和访问。作为主研参加国家自然科学基金、教育部博士点基金8项,在国际国内学术期刊上发表论文20余篇。中国生理学会呼吸生理专业委员会委员,四川省生理科学会理事,四川省生理科学会生理学专业委员会委员兼秘书。

    近年来发表的文章

    Li H, Chen L, Hou XF,Zhou H, Zheng Y. Hydrogen sulfide attenuates hypoxia-induced respiratory suppression in anesthetized adult rats. Respiratory Physiology & Neurobiology. 220:1-9, 2016.

    Ding Y, Hou XF, Chen L,Zhou H, Gong YJ, Dai LQ, Zheng Y*. Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats. Journal of the Neurological Sciences. 361:101-111, 2016.

    Lei F, Yan X, Zhao FS, Zhang SF, Zhang QL,Zhou H, Zheng Y. Impairment of central chemoreception in neonatal rats induced by maternal cigarette smoke exposure during pregnancy. PLOS ONE, DOI: 10.1371/journal. pone. 0137362, 2015.

    Zhou H,Wang J, Jiang JY, Stavrovskaya IG, Li MC, Li W, Wu QF, Zhang XM, Luo CL, Zhou SH, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. The Journal of Neuroscience. 34(8): 2967-2978, 2014.

    Li H, Hou XF, Ding Y, Nie LH,Zhou H, Nie Z, Tang YH, Chen L, Zheng Y. Effects of H2S on the central regulation of respiration in adult rats. Neuroreport. 25:358-366,2014.

    Ding Y, Hou XF, Chen L, Li H, Tang YH,Zhou H, Zhao S, Zheng Y. Protective action of Tetramethylpyrazine on medulla oblongata in rats with chronic hypoxia. Autonomic Neuroscience: Basic and Clinical. 173:45-52, 2013.

    Li MQ, Nie LH, Hu YJ, Yan X, Xue L, Chen L,Zhou H, Zheng Y. Chronic intermittent hypoxia promotes expression of 3-mercaptopyruvate sulfurtransferase in adult rat medulla oblongata. Autonomic Neuroscience: Basic and Clinical. 179:84-89, 2013.

    Chen L, Zhang J, Ding Y, Li H, Nie LH,Zhou H, Tang YH, Zheng Y. Site-specific hydrogen sulfide-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats. Neuroscience. 233:118-126, 2013.

    Chen L, Zhang J, Ding Y, Li H, Nie LH, Yan X,Zhou H, Zheng Y*. KATP channels of parafacial respiratory group (pFRG) neurons are involved in H2S-mediated central inhibition of respiratory rhythm in medullary slices of neonatal rats. Brain Research. 1527:141-148, 2013.

    Nie LH, Hu YJ, Yan X, Li MQ, Chen L, Li H, Li X,Zhou H, Zheng Y. The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure. Respiratory Physiology & Neurobiology. 188:29-38, 2013.

    Chen L, Zhang J, He Y, Pan JG,Zhou H, Li H, Tang YH, Zheng Y. Contribution of BKCa channels of neurons in rostral ventrolateral medulla to CO-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats. Respiratory Physiology & Neurobiology. 182:93–99, 2012.

    Pandya RS, Mao LJ,Zhou H, Zhou SH, Zeng J, Popp AJ, Wang X. Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms. Central Nervous System Agents in Medicinal Chemistry. 2011; 11(2): 81–97

    Zhang J, He Y, Ding Y,Zhou H, Tang YH, Chen L, Zheng Y. Nitric oxide synthase expression in the medullary respiratory related nuclei and its involvement in CO-mediated central respiratory effects in neonatal rats. Brain Research Bulletin. 84:258–263, 2011.

    Pan JG, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*. Protective action of endogenously generated H2S on hypoxia-induced respiratory suppression and its relation to antioxidation and down-regulation of c-fos mRNA in medullary slices of neonatal rats. Respiratory Physiology & Neurobiology. 178:230–234, 2011.

    Pan JG, Hu HY, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*. Protective effect of hydrogen sulfide on hypoxic respiratory suppression in medullary slice of neonatal rats. Respiratory Physiology & Neurobiology. 171:181-186, 2010.

    Zhang J, Chen L, He Y, Ding Y,Zhou H, Hu HY, Tang YH, Zheng Y. Large-conductance calcium-activated potassium channels in the neurons of pre-Bötzinger complex and their participation in the regulation of central respiratory activity in neonatal rats. Neuroscience Letters. 481:159-163, 2010.

    近年来主编、参编教材:

    《人体解剖生理学》(国家卫生和计划生育委员会“十三五”规划教材,国家高等医药教材建设研究会“十三五”规划教材),主编:周华崔慧先.第7版,北京:人民卫生出版社,2016年(主编)

    《生理学》(普通高等教育“十二五”规划教材),主编:胡志安王莎莉.第1版,北京:科学出版社,2014年(副主编)

    《生理学学习指导及习题集》(国家卫生和计划生育委员会“十二五”规划教材配套教材,国家高等医药教材建设研究会“十二五”规划教材配套教材),主编:祁金顺罗自强.第1版,北京:人民卫生出版社,2016年(参编)

    《生理学》(国家医学数字教材,全国高等学校五年制本科临床医学专业国家卫生和计划生育委员会“十二五”规划数字教材),主编:朱大年王庭槐.第1版,北京:人民卫生出版社,2015年(参编)

    地址:

    四川成都人民南路3段17号,610041

    联系方式:

    电话: 86-28-85503048

    传真:86-28-85503204

    邮箱: zhouhua_01@163.com

                       

    ZhouHua, Ph.D.

    Professor

    Department of Physiology

    West China School of Basic Medical Sciences & Forensic Medicine

    Sichuan University

    Address:

    Room 414, Yifu building

    No.17 People's South Road,Chengdu,610041

    Phone Number:86-28-85503048

    Fax Number:86-28-85503204

    Email Address:zhouhua_01@163.com

    Dr. Zhou mainresearch interests lie in the study of neuronal excitability and network synchronization within the mammalian central nervous system. Using EEG recording invivoand whole-cell ion currents recording on acute isolated hippocamal neurons and on hippocampal slices invitro, she investigated channel mechanisms of epileptogenesis in Tutin (a chemical convulsant derived from Chinese herbs) induced epileptic rats. Another study is to explore the protective mechanism of neuroprotective agents on ischemic neurons.she has been participating in research works of the National Natural Science Funds and Doctoral Funds of Ministry of Education.

    She went to the University of Hong Kong, and Brigham and Women 's Hospital affiliated to Harvard Medical School for academic research and interview. She has published more than 20 papers in the international and domestic academic journals. She serves as a member of Chinese society of physiology, specialized committee of respiratory physiology, and the secretary and a memberofphysiology specialized committee of Sichuan provincial physiological science society.

    Education and Training

    Xi’an Medical University in 1987, Bachelor’s degree in medicine

    West China University of Medical Sciences in 1997,Master’s degree in medicine

    Sichuan University in 2005,Ph.D.

    degree from She is a professor of physiology at Sichuan University. In the field of teaching, she has long been engaged in the teaching of undergraduate and graduate students for a long time and won many awards for educational reform projects and teaching achievements.

    Area of Interest

    Neurobiology, Neuroelectrophysiology, CellApoptosis, Cell Signing


    SelectedPublications

    Li H, Chen L, Hou XF,Zhou H, Zheng Y.Hydrogen sulfide attenuates hypoxia-induced respiratory suppression in anesthetized adult rats. Respiratory Physiology & Neurobiology. 220:1-9, 2016.

    Ding Y, Hou XF, Chen L,Zhou H, Gong YJ, Dai LQ, Zheng Y*. Heme oxygenase-1 dependant pathway contributes to protection by tetramethylpyrazine against chronic hypoxic injury on medulla oblongata in rats. Journal of the Neurological Sciences. 361:101-111, 2016.

    Lei F, Yan X, Zhao FS, Zhang SF, Zhang QL,Zhou H, Zheng Y. Impairment of central chemoreception in neonatal rats induced by maternal cigarette smoke exposure during pregnancy. PLOS ONE, DOI: 10.1371/journal. pone. 0137362, 2015.

    Zhou H,Wang J, Jiang JY, Stavrovskaya IG, Li MC, Li W, Wu QF, Zhang XM, Luo CL, Zhou SH, Sirianni AC, Sarkar S, Kristal BS, Friedlander RM, Wang X. N-acetyl-serotonin offers neuroprotection through inhibiting mitochondrial death pathways and autophagic activation in experimental models of ischemic injury. The Journal of Neuroscience. 34(8): 2967-2978, 2014.

    Li H, Hou XF, Ding Y, Nie LH,Zhou H, Nie Z, Tang YH, Chen L, Zheng Y. Effects of H2S on the central regulation of respiration in adult rats. Neuroreport. 25:358-366,2014.

    Ding Y, Hou XF, Chen L, Li H, Tang YH,Zhou H, Zhao S, Zheng Y. Protective action of Tetramethylpyrazine on medulla oblongata in rats with chronic hypoxia. Autonomic Neuroscience: Basic and Clinical. 173:45-52, 2013.

    Li MQ, Nie LH, Hu YJ, Yan X, Xue L, Chen L,Zhou H, Zheng Y. Chronic intermittent hypoxia promotes expression of 3-mercaptopyruvate sulfurtransferase in adult rat medulla oblongata. Autonomic Neuroscience: Basic and Clinical. 179:84-89, 2013.

    Chen L, Zhang J, Ding Y, Li H, Nie LH,Zhou H, Tang YH, Zheng Y. Site-specific hydrogen sulfide-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats. Neuroscience. 233:118-126, 2013.

    Chen L, Zhang J, Ding Y, Li H, Nie LH, Yan X,Zhou H, Zheng Y*. KATP channels of parafacial respiratory group (pFRG) neurons are involved in H2S-mediated central inhibition of respiratory rhythm in medullary slices of neonatal rats. Brain Research. 1527:141-148, 2013.

    Nie LH, Hu YJ, Yan X, Li MQ, Chen L, Li H, Li X,Zhou H, Zheng Y. The anti-apoptotic effect of hydrogen sulfide attenuates injuries to the medullary respiratory centers of neonatal rats subjected to in utero cigarette smoke exposure. Respiratory Physiology & Neurobiology. 188:29-38, 2013.

    Chen L, Zhang J, He Y, Pan JG,Zhou H, Li H, Tang YH, Zheng Y. Contribution of BKCa channels of neurons in rostral ventrolateral medulla to CO-mediated central regulation of respiratory rhythm in medullary slices of neonatal rats. Respiratory Physiology & Neurobiology. 182:93–99, 2012.

    Pandya RS, Mao LJ,Zhou H, Zhou SH, Zeng J, Popp AJ, Wang X. Central Nervous System Agents for Ischemic Stroke: Neuroprotection Mechanisms. Central Nervous System Agents in Medicinal Chemistry. 2011; 11(2): 81–97

    Zhang J, He Y, Ding Y,Zhou H, Tang YH, Chen L, Zheng Y. Nitric oxide synthase expression in the medullary respiratory related nuclei and its involvement in CO-mediated central respiratory effects in neonatal rats. Brain Research Bulletin. 84:258–263, 2011.

    Pan JG, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*. Protective action of endogenously generated H2S on hypoxia-induced respiratory suppression and its relation to antioxidation and down-regulation of c-fos mRNA in medullary slices of neonatal rats. Respiratory Physiology & Neurobiology. 178:230–234, 2011.

    Pan JG, Hu HY, Zhang J,Zhou H, Chen L, Tang YH, Zheng Y*. Protective effect of hydrogen sulfide on hypoxic respiratory suppression in medullary slice of neonatal rats. Respiratory Physiology & Neurobiology. 171:181-186, 2010.

    Zhang J, Chen L, He Y, Ding Y,Zhou H, Hu HY, Tang YH, Zheng Y. Large-conductance calcium-activated potassium channels in the neurons of pre-Bötzinger complex and their participation in the regulation of central respiratory activity in neonatal rats. Neuroscience Letters. 481:159-163, 2010.

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