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黄 宁

发布时间:2016-05-10      作者:学院办公室      审核:      编辑:      点击:
审核人

    教授

    四川大学华西基础医学与法医学院病理生理学教研室

    通讯地址:

    四川省成都市人民南路三段17号四川大学华西校区基础医学与法医学院,病理生理学教研室

    电话:+86-13880089687 Email: huangpanxiao@sina.com

    黄宁教授,医学博士,博士生导师。中国病理生理学会理事,中国病理生理学会炎症发热感染低温专业委员会副主任委员。四川省生理科学会理事长。四川省学术与技术带头人,四川省有突出贡献专家,四川省卫生厅学术与技术带头人,四川省病理生理学精品课程的负责人。四川大学国家“理科基础科学研究和教学人才培养基地”(基础医学)及211重点学科建设学术带头人之一。病理生理教研室主任。曾任四川大学华西基础医学与法医学院副院长,CMB细胞分子病理生理学重点学科负责人,四川大学“985”工程创新药物平台骨干。负责和主研过国家自然科学基金及CMB国际合作科研10余项,主编和参编专著教材7部,国内外发表科研论文100余篇,获四川省科技进步二等奖、国家发明专利各1项。四川大学学报(医学版)、中国病理生理学杂志、中国抗生素杂志现编委。

     

    教育及工作经历:

    1985年毕业于华西医科大学临床医学系,留校任教至今。先后获得医学硕士学位和医学博士学位,并先后晋升为讲师、副教授和教授。

     

    研究领域:

    天然免疫与炎症基因调控和分子信号;药物靶点及信号通路;天然免疫的表观遗传学调控机制;天然免疫与人类重大疾病。

    代表作:

    1.Liu K, Wang X, Sha K, et al. Nuclear protein HMGN2 attenuates pyocyanin-induced

    oxidative stress via Nrf2 signaling and inhibits Pseudomonas aeruginosa internalization in A549 cells. Free Radic Bio Med. 2017; 108:404-417.

    2.Xu Q, Liu X, Wang X, et al. Growth arrest-specific protein 7 regulates the murine

    M1 alveolar macrophage polarization. Immunol Res. 2017; 65(5):1065-1073.

    3.Li H, Shen X, Zhou X, et al. Antibacterial mechanism of high-mobility group

    nucleosomal-binding domain 2 on the Gram-negative bacteria Escherichia coli.

    J Zhejiang Univ Sci B. 2017; 18(5):410-420.

    4.Teng Y, Miao J, Shen X,et al. The modulation of MiR-155 and MiR-23a manipulates Klebsiella pneumoniae Adhesion on Human pulmonary Epithelial cells via Integrin α5β1 Signaling. Sci Rep. 2016; 6:31918.

    5.Shen X, Teng Y, Sha K, et al. Dietary flavonoid luteolin attenuates uropathogenic Escherichia. Coli invasion of the urinary bladder. Biofactors. 2016; 42(6):674-685.

    6.Yang X, Sha K, Xu G, et al. Subinhibitory Concentrations of Allicin Decrease

    UropathogenicEscherichia coli(UPEC) Biofilm Formation, Adhesion Ability, and

    Swimming Motility. Int J Mol Sci. 2016; 17(7):979.

    7.Wang X, Li J, Chen S, et al. Knockdown of HMGN2 increases the internalization of Klebsiella pneumoniaeby respiratory epithelial cells through the regulation of α5β1

    integrin expression:[J]. Int J Mol Med. 2016; 38(3):737-746.

    8.Xiong F, Liu K, Zhang F, et al. MiR-204 inhibits the proliferation and invasion of

    renal cell carcinoma by inhibiting RAB22A expression. Oncol Rep. 2016; 35(5):3000-3008.

    9.Xu G, Shi H, Ren L, et al. Enhancing the anti-colon cancer activity of quercetin by

    self-assembled micelles. Int J Nanomedicine. 2015; 10:2051-2063.

    10.Zheng S, Ren L, Li H, et al. High-mobility group nucleosome-binding domain 2

    protein inhibits the invasion of Klebsiella pneumoniae into mouse lungs in vivo.

    Mol Med Rep. 2015; 12(1):1279-85.

    11.Shen X, Ren L, Teng Y, et al. Luteolin decreases the attachment, invasion and

    cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation. Food Chem Toxicol. 2014; 72:204-11.

    12.Xiang G, Deng X, Wei X, et al. Novel thermosensitive hydrogel for preventing formation of abdominal adhesions. Int J Nanomedicine. 2013; 8:2453-63.

    13.Yang X, Huang N. Berberine induces selective apoptosis through the AMPK mediated mitochondrial/caspase pathway in hepatocellular carcinoma.

    Mol Med Rep. 2013; 8(2):505-10.

    14.Zheng F J, Shi L, Yang J, et al. Effect of tea polyphenols on the adhesion of highly metastatic human lung carcinoma cell lines to endothelial cells in vitro.[J].

    Asian Pac J Cancer Prev. 2012; 13(8):3751-5.

    15.Deng LX, Wu GX, Cao Y, et al. The chromosomal protein HMGN2 mediates

    lipopolysaccharide-induced expression of β-defensins in A549 cells. FEBS J. 2011; 278(12):2152-66.

    16.Cao Y, Wu G, Fan B, et al. High mobility group nucleosomal binding domain 2

    protein protects bladder epithelial cells from Klebsiella pneumoniae invasion.

    Biol Pharm Bull. 2011; 34(7):1065-71.

    17.Deng L, Pan X Y, Wang L, et al. Hemoglobin and its derived peptides may

    play a role in the antibacterial mechanism of the vagina. Hum Reprod. 2009; 24(1):211-8.

    18.Li M, Pan X, Li Y, et al. Purification of antimicrobial factors from

    human cervical mucus. Hum Reprod. 2007; 22(7):1810-5.

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